Intestinal Barrier Function TestingBioHealth logo

Healthy function of the intestinal barrier is essential to
disease prevention and overall optimal health. Leaky gutis known to cause numerous autimmune diseases.

BioHealth has the technology to inform you and your patients of its status. Move away from primitive lactose-mannitol (PET) techniques and come to the elite diagnostic source.

Lab testing to assess: the integrity of the gut's mucosal barrier; antigen penetration; dysbiosis; leaky gut; malabsorption; dietary protein sensitivity; secretory IgA production; intestinal permeability; crypt hyperplasia; antibody response to: Candida, aerobic and anaerobic bacteria, and dietary proteins.

To Request Testing Services
Health Professionals HERE
General Public HERE

Or call 800-570-2000 to start testing.

Lab Testing

Resources & Research

  • BioHealth Diagnostics Screens
    • Test BHD #304 - Intestinal Barrier Function Screen on Saliva
      - Single sIgA and IgA+IgM to: Combined dietary proteins (Wheat/gliadin, corn, soy, cow's milk, egg); aerobic bacteria (Escherichia coli and E. enterococcus); anaerobic bacteria (Bacteroides fragilis and Clostridium perfringens); Candida albicans yeast
  • Call 800-570-2000 or visit this link to start testing.

Overview

A new generation of testing for intestinal permeability.  This scientifically advanced assessment takes into consideration the individual patient’s immune system response to proteins and peptides (macromolecules) which, upon entry into the bloodstream, can challenge the immune system resulting in IgG, IgA and IgM antibody production against them.  In healthy, normal intestinal immune conditions, antigens are passed through the lumen into circulation, and for many people this common event does not evoke an overreaction in the systemic response.  However, for susceptible persons even this passage of antigens can erupt into the beginning of a neuroautoimmune disorder. 

The patented Intestinal Barrier Function screens not only provide a proper immune response assessment in regards to intestinal permeability (leaky gut), they also include evaluations of factors important to the overall health of the intestinal tract.  GI imbalance cannot be understood fully, in its diagnostic and therapeutic implications, without the coordination of the intestinal flora, their toxins (LPS) and dietary proteins.  Use of the Intestinal Barrier Function Screen gives clinicians etiologically based analysis of intestinal integrity and its accurate ELISA methodology provides quantitative results which can be used in case management of intestinal-related health problems.

Optimal health is not possible without proper Intestinal Barrier Function.  Being on the front lines in defending the body, the mucosal layer, the extrinsic barrier, of the GI tract is exposed to a multitude of stressors, antigens, pathogens, imbalances of neurotransmitters, toxins and medications, and sometimes this barrage can weaken and break down the protective barrier.  What follows the loss of mucosal immune tolerance is a cascade beginning with the formation of immune complexes and inflammatory cytokine responses.  These abnormal levels of regulatory cytokine production such as in IL-10 and TGF-beta lead to enhanced intestinal permeability in which the tight junctions in the intrinsic barrier open and allow the passage of dietary proteins and peptides into the blood stream.  Commonly known as leaky gut, enhanced gut permeability is the precursor to autoimmune disorders such as Type I Diabetes, RA, Lupus, MS and autoimmune hypothyroidism.  It is also the pathway to neurologic dysfunction associated with gluten intolerance, Celiac disease, Autism and ADHD.

Healthy Barrier to the Left/
Sick Barrier to the Right

Mucosal Barrier Comparison

Your First-Line Immune Defense

The mucosal barrier—your first-line immune defense—refers to all of the mucous membranes that comprise the primary interface between the external environment and the internal environment of the body. This mucosal barrier lets beneficial things into your general circulation and keeps harmful ones out.

To clarify this, an analogy can be made between the earth’s ozone layer and your body’s mucosal barriers. The ozone layer lets the right amount of sunlight through, sustaining life on earth; your mucosal barriers allow nutrients through, sustaining your health. The ozone layer prevents harmful radiation from getting through; the mucosal barriers prevent infectious agents and allergens from invading your body. But just as our planet has a damaged ozone layer, many of us have damaged mucosal barriers. Consequently, we are not protected from harmful substances such as parasites, viruses, and bacteria.

No disease or symptom needs to be present to warrant protecting the mucosal barrier of the intestines; keeping it healthy helps to keep us strong and disease-resistant. Strengthening the gut lining is applicable to relieving and avoiding the impacts of asthma, arthritis, food allergies, ulcers, Crohn’s, ulcerative colitis, celiac disease, autoimmune diseases, alcoholism, chronic fatigue, joint pain, migraines, diarrhea, parasitic infections, dysbiosis, candidiasis, multiple sclerosis, and diabetes, all of which can have their origin in harmful substances penetrating through the intestines.

Components
© 2009 BioHealth Diagnostics

Stress and Environment and Gut Disorders
© 2009 Aristo Vojdani, PhD

Gut Brain
© 2009 Aristo Vojdani, PhD

Proposed role of abnormal intestinal permeability in the pathogenesis of
autoimmune disease targeting intestinal tissue and different organs. (Vojdani, PhD)

Pathogenesis of Autoimmunity
© 2009 Aristo Vojdani, PhD

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